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edit Mitogen-activated protein kinase kinase 5 PDB rendering based on 1wi0. Available structures PDB 1wi0, 2npt, 2o2v Identifiers Symbols MAP2K5; HsT17454; MAPKK5; MEK5; PRKMK5 External IDs OMIM: 602520 MGI: 1346345 HomoloGene: 68937 GeneCards: MAP2K5 Gene Gene Ontology Molecular function • nucleotide binding • protein serine/threonine kinase activity • protein-tyrosine kinase activity • ATP binding • transferase activity Cellular component • spindle Biological process • MAPKKK cascade • protein amino acid phosphorylation • signal transduction • heart development Sources: Amigo / QuickGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5607 23938 Ensembl ENSG00000137764 ENSMUSG00000058444 UniProt Q13163 Q3TM51 RefSeq (mRNA) NM_002757 XM_981477 RefSeq (protein) NP_002748 XP_986571 Location (UCSC) Chr 15: 65.62 - 65.89 Mb Chr 9: 62.96 - 63.18 Mb PubMed search [1] [2] Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene.[1][2] The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.[2] Interactions MAP2K5 has been shown to interact with MAPK7,[1] MAP3K2,[3] Protein kinase Mζ[4] and MAP3K3.[3][5] References ^ a b Zhou G, Bao ZQ, Dixon JE (Jun 1995). "Components of a new human protein kinase signal transduction pathway". J Biol Chem 270 (21): 12665–9. PMID 7759517.  ^ a b "Entrez Gene: MAP2K5 mitogen-activated protein kinase kinase 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5607.  ^ a b Sun, W; Kesavan K, Schaefer B C, Garrington T P, Ware M, Johnson N L, Gelfand E W, Johnson G L (Feb. 2001). "MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway". J. Biol. Chem. (United States) 276 (7): 5093–100. doi:10.1074/jbc.M003719200. ISSN 0021-9258. PMID 11073940.  ^ Diaz-Meco, M T; Moscat J (Feb. 2001). "MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling". Mol. Cell. Biol. (United States) 21 (4): 1218–27. doi:10.1128/MCB.21.4.1218-1227.2001. ISSN 0270-7306. PMID 11158308.  ^ Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (Feb. 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216.  Further reading English JM, Vanderbilt CA, Xu S, et al. (1996). "Isolation of MEK5 and differential expression of alternatively spliced forms.". J. Biol. Chem. 270 (48): 28897–902. doi:10.1074/jbc.270.48.28897. PMID 7499418.  Kato Y, Kravchenko VV, Tapping RI, et al. (1998). "BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C.". EMBO J. 16 (23): 7054–66. doi:10.1093/emboj/16.23.7054. PMID 9384584.  Kato Y, Tapping RI, Huang S, et al. (1998). "Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor.". Nature 395 (6703): 713–6. doi:10.1038/27234. PMID 9790194.  English JM, Pearson G, Hockenberry T, et al. (1999). "Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control.". J. Biol. Chem. 274 (44): 31588–92. doi:10.1074/jbc.274.44.31588. PMID 10531364.  Chao TH, Hayashi M, Tapping RI, et al. (2000). "MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway.". J. Biol. Chem. 274 (51): 36035–8. doi:10.1074/jbc.274.51.36035. PMID 10593883.  Sun W, Kesavan K, Schaefer BC, et al. (2001). "MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway.". J. Biol. Chem. 276 (7): 5093–100. doi:10.1074/jbc.M003719200. PMID 11073940.  Diaz-Meco MT, Moscat J (2001). "MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling.". Mol. Cell. Biol. 21 (4): 1218–27. doi:10.1128/MCB.21.4.1218-1227.2001. PMID 11158308.  Nicol RL, Frey N, Pearson G, et al. (2001). "Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy.". EMBO J. 20 (11): 2757–67. doi:10.1093/emboj/20.11.2757. PMID 11387209.  Dinev D, Jordan BW, Neufeld B, et al. (2001). "Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells.". EMBO Rep. 2 (9): 829–34. doi:10.1093/embo-reports/kve177. PMID 11520859.  Weldon CB, Scandurro AB, Rolfe KW, et al. (2002). "Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray.". Surgery 132 (2): 293–301. doi:10.1067/msy.2002.125389. PMID 12219026.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  Mehta PB, Jenkins BL, McCarthy L, et al. (2003). "MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion.". Oncogene 22 (9): 1381–9. doi:10.1038/sj.onc.1206154. PMID 12618764.  Mody N, Campbell DG, Morrice N, et al. (2003). "An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro.". Biochem. J. 372 (Pt 2): 567–75. doi:10.1042/BJ20030193. PMID 12628002.  Huang J, Tu Z, Lee FS (2003). "Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity.". Biochem. Biophys. Res. Commun. 303 (2): 532–40. doi:10.1016/S0006-291X(03)00387-5. PMID 12659851.  Lamark T, Perander M, Outzen H, et al. (2003). "Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.". J. Biol. Chem. 278 (36): 34568–81. doi:10.1074/jbc.M303221200. PMID 12813044.  Cameron SJ, Abe J, Malik S, et al. (2004). "Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation.". J. Biol. Chem. 279 (2): 1506–12. doi:10.1074/jbc.M308755200. PMID 14583600.  Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.  Raviv Z, Kalie E, Seger R (2004). "MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation.". J. Cell. Sci. 117 (Pt 9): 1773–84. doi:10.1242/jcs.01040. PMID 15075238.  v • d • e PDB Gallery 1wi0: Solution structure of the PB1 domain of mouse mitogen activated protein kinase kinase 5 (MAP2K5)   2npt: Crystal Structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 2 phox domain (MAP3K2-phox)   2o2v: Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox)   This article on a gene on chromosome 15 is a stub. You can help Wikipedia by expanding it. v • d • e v • d • e Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)   Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1, LATS2, MAST1, MAST2, STK38, STK38L, CIT, ROCK1, SGK, SGK2, SGK3, Protein kinase B (AKT1, AKT2, AKT3), Ataxia telangiectasia mutated, Mammalian target of rapamycin, EIF-2 kinases (PKR, HRI, EIF2AK3, EIF2AK4), Wee1 (WEE1) Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1, PDK2, PDK3 Dephospho-(reductase kinase) kinase (EC 2.7.11.3) AMP-activated protein kinase α (PRKAA1, PRKAA2) · β (PRKAB1, PRKAB2) · γ (PRKAG1, PRKAG2, PRKAG3) (3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)) (EC 2.7.11.4) BCKDK, BCKDHA, BCKDHB (isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5) IDH2, IDH3A, IDH3B, IDH3G (tyrosine 3-monooxygenase) kinase (EC 2.7.11.6) STK4 Myosin-heavy-chain kinase (EC 2.7.11.7) Aurora kinase (Aurora A kinase, Aurora B kinase) Fas-activated serine/threonine kinase (EC 2.7.11.8) FASTK, STK10 Goodpasture-antigen-binding protein kinase (EC 2.7.11.9) - IκB kinase (EC 2.7.11.10) CHUK, IKK2, TBK1, IKBKE, IKBKG, IKBKAP cAMP-dependent protein kinase (EC 2.7.11.11) Protein kinase A, PRKACG, PRKACB, PRKACA, PRKY cGMP-dependent protein kinase (EC 2.7.11.12) Protein kinase G, PRKG1 Protein kinase C (EC 2.7.11.13) Protein kinase C, Protein kinase Cζ, PKC alpha, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCG, PRKCI, PRKCQ, Protein kinase N1, PKN2, PKN3, Rhodopsin kinase (EC 2.7.11.14) Rhodopsin kinase Beta adrenergic receptor kinase (EC 2.7.11.15) Beta adrenergic receptor kinase, Beta adrenergic receptor kinase-2 G-protein coupled receptor kinases (EC 2.7.11.16) GRK4, GRK5, GRK6 Ca2+/calmodulin-dependent (EC 2.7.11.17) BRSK2, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, MLCK, CASK, CHEK1, CHEK2, DAPK1, DAPK2, DAPK3, STK11, MAPKAPK2, MAPKAPK3, MAPKAPK5, MARK1, MARK2, MARK3, MARK4, MELK, MKNK1, MKNK2, NUAK1, NUAK2, OBSCN, PASK, PHKG1, PHKG2, PIM1, PIM2, PKD1, PRKD2, PRKD3, PSKH1, SNF1LK2, KIAA0999, STK40, SNF1LK, SNRK, SPEG, TSSK2, Kalirin, TRIB1, TRIB2, TRIB3, TRIO, Titin, DCLK1 Myosin light-chain kinase (EC 2.7.11.18) MYLK, MYLK2, MYLK3, MYLK4 Phosphorylase kinase (EC 2.7.11.19) PHKA1, PHKA2, PHKB, PHKG1, PHKG2 Elongation factor 2 kinase (EC 2.7.11.20) EEF2K, STK19   Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30) Polo kinase (EC 2.7.11.21) PLK1, PLK2, PLK3, PLK4 Cyclin-dependent kinase (EC 2.7.11.22) CDK1, CDK2, CDKL2, CDK3, CDK4, CDK5, CDKL5, CDK6, CDK7, CDK8, CDK9, CDK10, CDC2L5, CRKRS, PCTK1, PCTK2, PCTK3, PFTK1, CDC2L1 (RNA-polymerase)-subunit kinase (EC 2.7.11.23) RPS6KA5, RPS6KA4, P70S6 kinase, P70-S6 Kinase 1, RPS6KB2, RPS6KA2, RPS6KA3, RPS6KA1, RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated (MAPK1, MAPK3, MAPK4, MAPK6, MAPK7, MAPK12, MAPK15), C-Jun N-terminal (MAPK8, MAPK9, MAPK10), P38 mitogen-activated protein (MAPK11, MAPK13, MAPK14) MAP3K (EC 2.7.11.25) MAP kinase kinase kinases (MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8) RAFs (ARAF, BRAF, KSR1, KSR2) MLKs (MAP3K12, MAP3K13, MAP3K9, MAP3K10, MAP3K11, MAP3K7, ZAK) CDC7 Tau-protein kinase (EC 2.7.11.26) TPK1, TTK, GSK-3 (acetyl-CoA carboxylase) kinase (EC 2.7.11.27) - Tropomyosin kinase (EC 2.7.11.28) - Low-density-lipoprotein receptor kinase (EC 2.7.11.29) - Receptor protein serine/threonine kinase (EC 2.7.11.30) Bone morphogenetic protein receptors (BMPR1, BMPR1A, BMPR1B, BMPR2), ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, Anti-Müllerian hormone receptor   Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7 B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6